I am sorry to tell you that I do not agree with your suggestion ______ your knowledge.
Show answer & explanation
Correct answer: D
Explanation
The sentence states that the speaker does not agree to the suggestion given by someone, although he acknowledges that the person giving the suggestion is knowledgeable. Both the statements given by the speaker are contradictory.
Here the most appropriate word that fits in the blank is ‘despite’ because "Despite" is a preposition used to show contrast, meaning "notwithstanding" or "regardless of". It is followed by a noun, a pronoun (e.g., this, that, what), or a gerund, never a full clause.